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Specific genetic alterations of breast tumors lead to Yo paraneoplastic cerebellar degeneration

Previous findings of research groups in Paris and Lyon, France, investigated the genetic basis of paraneoplastic cerebellar degenerations with anti-Yo antibodies (Yo-PCD) associated with ovarian cancers. Recent results suggest that this auto-immune response against neuronal antigens expressed by tumor cells is also associated with a distinct class of hormone receptor-negative HER2-enriched breast cancers.