In patients with radiologically isolated syndrome (RIS), white matter paramagnetic rim lesions (PRL) can predict the development of multiple sclerosis (MS), new study findings show.
Previous studies have found white matter PRLs and central vein sign lesions (CVSL) in patients with RIS. The presence of PRLs indicates chronic active demyelination, and CVSLs suggests perivenular demyelination. How these factors relate to the likelihood of developing MS is unknown.